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hippocampus (not shown).
C, cerebellum; Th, thalamus; A, amygdala; TL, temporal lobe; ST, striatum; PFC, prefrontal
cortex; OC, occipital cortex. Some serotonin receptor types
Serotonin receptors: 7 types, 14 subtypes!
– high concentration in hippocampus, amygdala, septal area
– agonists are anxiolytic and antidepressant
– some suggestion of antiaggression
(low conc. of 5HT1a receptors in frontal cortex of violent
– high concentration in the neocortex and in parts of the subcortex
– role in thermoregulation, appetite and vegetative functions
– in subcortex, involved in gating sensory information (LSD) Dopamine, noradrenaline and serotonin:
intense interrelationship in the regulation of ‘mood’ 6 Biogenic amines
– • Dopamine
Epinephrine (adrenaline) Some amino acids as neurotransmitter Indolamines
… Intense interrelationship between various biogenic amines
in the regulation of wake and sleep GABA Amino acids
• Aspartate Gamma-amino-buturic acid
• Primary inhibitory neurotransmitter in CNS
Derived from glutamate: marker enzyme is Glutamic Acid Decarboxylase • Strong relationship with dopamine in nigrostriatal system and
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This note was uploaded on 05/28/2010 for the course GE BIOL020000 taught by Professor Luccrevits during the Spring '10 term at Ghent University.
- Spring '10