C cerebellum th thalamus a amygdala tl temporal lobe

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Unformatted text preview: e hippocampus (not shown). C, cerebellum; Th, thalamus; A, amygdala; TL, temporal lobe; ST, striatum; PFC, prefrontal cortex; OC, occipital cortex. Some serotonin receptor types Serotonin receptors: 7 types, 14 subtypes! • 5HT1a – high concentration in hippocampus, amygdala, septal area – agonists are anxiolytic and antidepressant – some suggestion of antiaggression (low conc. of 5HT1a receptors in frontal cortex of violent suicide victims) • 5HT2 – high concentration in the neocortex and in parts of the subcortex – role in thermoregulation, appetite and vegetative functions – in subcortex, involved in gating sensory information (LSD) Dopamine, noradrenaline and serotonin: intense interrelationship in the regulation of ‘mood’ 6 Biogenic amines • Acetylcholine • Catecholamines – – – • Dopamine Norepinephrine (noradrenaline) Epinephrine (adrenaline) Some amino acids as neurotransmitter Indolamines – – Serotonin Histamine • • • • GABA Glutamate Aspartate … Intense interrelationship between various biogenic amines in the regulation of wake and sleep GABA Amino acids • GABA • Glutamate • Aspartate Gamma-amino-buturic acid • Primary inhibitory neurotransmitter in CNS Derived from glutamate: marker enzyme is Glutamic Acid Decarboxylase • Strong relationship with dopamine in nigrostriatal system and mesolimbic system – GAB...
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This note was uploaded on 05/28/2010 for the course GE BIOL020000 taught by Professor Luccrevits during the Spring '10 term at Ghent University.

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