Dopamine degradates to dopac and the nocious products

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Unformatted text preview: is formed from tyrosine. Dopamine degradates to DOPAC and the nocious products: oxygenperoxide en hydroxyl radicals. Tyrosine Tyrosine hydroxylase Dihydroxyfenylalanine DOPA decarboxylase Dopamine Monoamino-oxidase (MAO) DOPAC Oxygenperoxide, hydroxyl radicals Waterstofperoxide & hydroxyl-radicalen 3 Dopamine systems Four central dopaminergic systems: Dopamine systems extrapyramidal system executive and memory reward mediated behavior •Nigro-striatal •Meso-limbic •Meso-cortical •Tubero-infundibular -Nigro-striatal path: dopaminergic neurons in substantia nigra project to the striatum Dopamine systems -Mesocortical path to frontal cortex (DLPFC) -Mesolimbic path to the limbic system Dopamine systems Putamen Caudate nucleus Nucleus accumbens Ventral tegmental area Amygdala Substantia nigra mesolimbic pathway Dopamine mediates reward mediated behavior D3 receptor nigrostriatal pathway D2 rec...
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