Unformatted text preview: eptor Missale C, et al. Physiol Rev 1998;78:189-225
Shafer RA, et al. Psychopharmacology (Berl) 1998;135:1-16 4 Noradrenaline Noradrenaline projections
to cortex, cerebellum and spinal cord Locus coeruleus:
a noradrenergic nucleus in the pons, at the bottom of the 4th vertricle Serotonin Noradrenergic functions Tryptofaan • Dorsal bundle and median forebrain bundle
– arousal, sleep-wake system
– autonomic functions
– reward and reinforcement
– affect (anxiety, mood) Tryptofaanhydroxylase
5-hydroxy-tryptophan Aromatic L-amino acid decarboxylase
Serotonine (5-HT) (5-hyroxy-tryptamine)
Monoamino-oxidase (MAO) • Implicated in drug addictions and withdrawal syndromes
5-HIAA Formed from tryptophane.
The enzyme monoamino-oxidase (MAO) degradates serotonin.
One of these products is 5-HIAA. 5 Serotonin
... Raphe nuclei in the brainstem
Projections (red arrows) from
the rostal (dorsal) raphe nucleus (RRN) and from
the caudal raphe nucleus (CRN)
There are also projections from the median raphe nucleus and from the RRN, for example to th...
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