Physiol rev 199878189 225 shafer ra et al

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Unformatted text preview: eptor Missale C, et al. Physiol Rev 1998;78:189-225 Shafer RA, et al. Psychopharmacology (Berl) 1998;135:1-16 4 Noradrenaline Noradrenaline projections to cortex, cerebellum and spinal cord Locus coeruleus: a noradrenergic nucleus in the pons, at the bottom of the 4th vertricle Serotonin Noradrenergic functions Tryptofaan • Dorsal bundle and median forebrain bundle – arousal, sleep-wake system – autonomic functions – reward and reinforcement – affect (anxiety, mood) Tryptofaanhydroxylase 5-hydroxytryptofaan 5-hydroxy-tryptophan Aromatic L-amino acid decarboxylase Serotonine (5-HT) (5-hyroxy-tryptamine) Monoamino-oxidase (MAO) • Implicated in drug addictions and withdrawal syndromes 5-HIAA Formed from tryptophane. The enzyme monoamino-oxidase (MAO) degradates serotonin. One of these products is 5-HIAA. 5 Serotonin Serotonin projections Involved in appetite, sleep, memory, impulsivity mood, ... Raphe nuclei in the brainstem Projections (red arrows) from the rostal (dorsal) raphe nucleus (RRN) and from the caudal raphe nucleus (CRN) There are also projections from the median raphe nucleus and from the RRN, for example to th...
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