1AD2BD8Bd01 - Human Brain Mapping: functional imaging of...

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1 Human Brain Mapping: functional imaging of the brain Ruth Seurinck Neurobiology – 2de Master Biochemie en biotechnologie 5 november 2009 Overview 1.Introduction 2. Some history 3. Functional MRI 4. Neurovascular coupling revisited 5. MR Spectroscopy 6. Transcranial Magnetic Stimulation 7. Structural Imaging Human Brain Mapping – Ruth Seurinck - 05/11/2009 Faculteit Psychologie en Pedagogische Wetenschappen – Vakgroep Experimentele psychologie 2
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2 Introduction: terminology Psychology Neuropsychology Human Brain Mapping Cognitive Neuroscience Human Brain Mapping – Ruth Seurinck - 05/11/2009 Faculteit Psychologie en Pedagogische Wetenschappen – Vakgroep Experimentele psychologie 3 Introduction: terminology Human Brain Mapping: b Functional neuroimaging (not structural imaging!) b “Non-invasive research techniques that map the functional organisation of the brain” b Task-related activity Human Brain Mapping – Ruth Seurinck – 05/11/2009 Faculteit Psychologie en Pedagogische Wetenschappen – Vakgroep Experimentele psychologie 4
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3 Introduction: two perspectives Human Brain Mapping – Ruth Seurinck - 05/11/2009 Faculteit Psychologie en Pedagogische Wetenschappen – Vakgroep Experimentele psychologie 5 Neurobiology Human Brain Mapping Polyak, 1957; Savoy, ‘01 Overview 1. Introduction 2.Some history 3. Functional MRI 4. Neurovascular coupling revisited 5. MR Spectroscopy 6. Transcranial Magnetic Stimulation 7. Structural Imaging Human Brain Mapping – Ruth Seurinck - 05/11/2009 Faculteit Psychologie en Pedagogische Wetenschappen – Vakgroep Experimentele psychologie 6
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4 Classic neuropsychological casestudies: Some history: case studies Human Brain Mapping – Ruth Seurinck - 05/11/2009 Faculteit Psychologie en Pedagogische Wetenschappen – Vakgroep Experimentele psychologie 7 Broca, 1861 Phineas Gage, 1848 Some history: Neurosurgery Human Brain Mapping – Ruth Seurinck - 05/11/2009 Faculteit Psychologie en Pedagogische Wetenschappen – Vakgroep Experimentele psychologie 8 Neurosurgery: b exposure of the brain during surgery while patient is conscious b b Still commonly used during surgery (epilepsy & brain tumors)
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5 Some history: EEG Human Brain Mapping – Ruth Seurinck - 05/11/2009 Faculteit Psychologie en Pedagogische Wetenschappen – Vakgroep Experimentele psychologie 9 b But what about the healthy brain? b Neurons produce ionic currents when transacting information b Electrophysiological signal can be registered during surgery b First studies in 1920’s experimented with sensors outside the human brain: EEG or ElectroEncephalyGraphy Some history: EEG Human Brain Mapping – Ruth Seurinck - 05/11/2009 Faculteit Psychologie en Pedagogische Wetenschappen – Vakgroep Experimentele psychologie 10 Used for functional brain mapping: Event-related Potential (ERP) or the fast change in EEG signal after the administration of a sensory stimulus
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This note was uploaded on 05/28/2010 for the course WE CHMOBI0000 taught by Professor Geertvanloo during the Spring '10 term at Ghent University.

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1AD2BD8Bd01 - Human Brain Mapping: functional imaging of...

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