les8_17112008 - Human Brain Mapping: functional imaging of...

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Human Brain Mapping: functional imaging of the brain Ruth Seurinck Neurobiology 2de Master Biochemie en biotechnologie 17 november 2008
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Overview 1. Introduction 2. Some history 3. Functional MRI 4. Neurovascular coupling revisited 5. MR Spectroscopy Human Brain Mapping Ruth Seurinck - 17/11/2008 Faculteit Psychologie en Pedagogische Wetenschappen Vakgroep Experimentele psychologie 2
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Introduction: terminology Psychology Neuropsychology Human Brain Mapping Cognitive Neuroscience Human Brain Mapping Ruth Seurinck - 17/11/2008 Faculteit Psychologie en Pedagogische Wetenschappen Vakgroep Experimentele psychologie 3
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Introduction: terminology Human Brain Mapping: Functional neuroimaging (not structural imaging!) “Non -invasive research techniques that map the functional organisation of the brain” Task-related activity Human Brain Mapping Ruth Seurinck - 17/11/2008 Faculteit Psychologie en Pedagogische Wetenschappen Vakgroep Experimentele psychologie 4
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Introduction: two perspectives Human Brain Mapping Ruth Seurinck - 17/11/2008 Faculteit Psychologie en Pedagogische Wetenschappen Vakgroep Experimentele psychologie 5 Neurobiology Human Brain Mapping D‟Esposito , „03 Polyak, 1957; Savoy , „01
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Classic neuropsychological casestudies: Some history: case studies Human Brain Mapping Ruth Seurinck - 17/11/2008 Faculteit Psychologie en Pedagogische Wetenschappen Vakgroep Experimentele psychologie 6 Broca, 1861 Phineas Gage, 1848
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Some history: Neurosurgery Human Brain Mapping Ruth Seurinck - 17/11/2008 Faculteit Psychologie en Pedagogische Wetenschappen Vakgroep Experimentele psychologie 7 Neurosurgery: exposure of the brain during surgery while patient is conscious Still commonly used during surgery (epilepsy & brain tumors)
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Some history: EEG Human Brain Mapping Ruth Seurinck - 17/11/2008 Faculteit Psychologie en Pedagogische Wetenschappen Vakgroep Experimentele psychologie 8 But what about the healthy brain? Neurons produce ionic currents when transacting information Electrophysiological signal can be registered during surgery First studies in 1920‟s experimented with sensors outside the human brain: EEG or ElectroEncephalyGraphy
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Some history: EEG Human Brain Mapping Ruth Seurinck - 17/11/2008 Faculteit Psychologie en Pedagogische Wetenschappen Vakgroep Experimentele psychologie 9 Used for functional brain mapping: Event-related Potential (ERP) or the fast change in EEG signal after the administration of a sensory stimulus
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Some history: EEG Human Brain Mapping Ruth Seurinck - 17/11/2008 Faculteit Psychologie en Pedagogische Wetenschappen Vakgroep Experimentele psychologie 10 Many clinical applications: epilepsy, sleep research, brain pathology, … High temporal resolution: ms Poor spatial resolution: very difficult to locate source of activation due to the inverse problem Direct measure of neuronal activity… alternatives?
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This note was uploaded on 05/28/2010 for the course WE CHMOBI0000 taught by Professor Geertvanloo during the Spring '10 term at Ghent University.

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les8_17112008 - Human Brain Mapping: functional imaging of...

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