Immunoles_4 - Immunology of omestic Animals Immunology of...

Info iconThis preview shows pages 1–14. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Immunology of omestic Animals Immunology of omestic Animals Immunology of omestic Animals Immunology of omestic Animals Immunology of omestic Animals Innate immunity: non-specific? • Discriminates between pathogens and self, as well as classes of pathogens, with pattern-recognition receptors (PRR): – Toll-like receptors, mannose-receptors, integrin-receptors, LPS-receptors – Recognise pathogen-associated molecular patterns (PAMP) • Helps in initiating the adaptive immune responses: cytokines, chemokines and APC • Interact with the adaptive immunity through receptors: – complement receptors (CR), immunoglobuline receptors (FcR) Immunology of omestic Animals Macrophages Classically activated M φ • Induced by pro-inflammatory molecules (INF- γ ) and bacterial products (LPS, CpG) • Secrete pro-inflammatory cytokines (IL-1, TNF- α , IL-12) • High activities of nitric oxide synthetase (iNOS) (arginine → NO) • Anti-invasive and cytotoxic activities Involved in Th1 responses Alternatively activated M φ • Induced by IL-4, IL-13 and anti- inflammatory molecules (glucocorticoids) • Secrete anti-inflammatory cytokines (TGF- β , IL-10) • High activities of arginase (arginine → L-ornithine and urea) • Involved in cleansing and reparative processes: fibrinolyse, elastase, collagenase, angiogenese, growth factors for fibroblasts • Suppression of T cell proliferation Involved in Th2 responses Immunology of omestic Animals Germain RN, Nature Medicine 2004 Immunology of omestic Animals Immunology of omestic Animals Immunology of omestic Animals Klinman DM, Nature Reviews Immunology 2004 Immunology of omestic Animals Passieve immuniteit Maternale immuniteit Colostrale immuniteit Lactogene immuniteit Systemische immuniteit:- vooral IgG- duurt 1-3 maanden Darmimmuniteit:- vooral IgA, IgG, IgM- duurt zolang gezoogd wordt Immunology of omestic Animals Placentatypes en antistoffenoverdracht Species Placentatype Aantal lagen Antistoffenoverdracht Mat Fet Placenta Darm Rund Paard Varken Epithelio- choriaal 3 3 - +++ Schaap Geit Syndesmo- choriaal 2 3 - +++ Hond Kat Endothelio- choriaal 1 3 + +++ Mens Hemo- choriaal 0 3 +++ - Immunology of...
View Full Document

This note was uploaded on 05/28/2010 for the course WE BIBI000000 taught by Professor Johangrooten during the Spring '10 term at Ghent University.

Page1 / 39

Immunoles_4 - Immunology of omestic Animals Immunology of...

This preview shows document pages 1 - 14. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online