Les_8_ppt_blackwhite

Les_8_ppt_blackwhite - • Witze et al 2007 798-799(left...

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A. Addition of functional groups: - Phosphorylation (2 groups) - Lipid modifications: N-myristoylation (2 groups) Prenylation (2 groups) Palmitoylation (2 groups) GPI anchoring (2 groups) - ADP ribosylation (/) - Acetylation (2 groups) - Methylation (2 groups) A. Addition of other proteins/peptides: -Ubiquitination (2 groups) -Sumoylation (2 groups) VII. Protein modifications
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groups • 18 (19) groups of 2 persons (1 of 3) • 37 (39) people
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Intention Articles on PTM: pdf files can be found at Minerva Answer the following questions in “telegram” style: 1. Process of modification: • What, donor, … • Coupled to AA X, how coupled, recognition motif/prediction,… • How: enzyme(s) involved, (ir)reversible, … • Recognition by protein domain? 2. (Special remarks) 3. Function(s) + 1 example 4. Assays PPP memory stick – max. 5 slides – Figures: use “camera” symbol to select – WC II: presentation + discussion
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Phosphorylation • Delom and Chevet, 2006: 1-4, 6-7 (P site mapping) • Mann et al., 2002: 261
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Unformatted text preview: • Witze et al., 2007: 798-799 (left column) N-myristoylation • Resh, 1999: 1-6 • Vilas et al., 2006: 6542-6543, 6547 Prenylation • Perez-Sala, 2007: 4456-4459 • Benetka et al., 2006: 1241-1249, 1255-1260 (titles) • Santos et al., 2002: assay Palmitoylation • Drisdel et al., 2006: 127-130 • Nadolski and Linder, 2007: 5202-5205 • Resh 2006: 1-2 GPI anchor formation • Orlean and Menon, 2007: 993-995, 1001-1002 • Reinders and Sickmann, 2007: 173 • Mayor and Riezman, 2005: 110-113 ε N-acetylation • Chapter 6 (only Ac of Lys):151-158 • Yang and Seto, 2007: 5310-5311 Methylation • Walsh: 121-135 Ubiquitination • Kerscher et al., 2006: 159-167 • Kaiser + Huang, 2005: 1-5 • Minmaugh et al., 1999: 418-422 (end of 2.2) • Pickart: figures • Hicke: figures • Check also for = with other UBLs Sumoylation • Geiss-Friedlander and Melchior, 2007 • Hay, 2007: 370-371 • protocols Work college II • presentations • discussion...
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  • Spring '10
  • JohanGrooten
  • Posttranslational modification, GPi, Drisdel et al., Kerscher et al., VII. Protein modifications, GPI anchor formation

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Les_8_ppt_blackwhite - • Witze et al 2007 798-799(left...

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