Glycobiology_Course_lesson_5

Glycobiology_Course_lesson_5 - Glycobiology Course IV...

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Glycobiology Session 3, slide 1 Glycobiology Course IV Clinical diagnostics based on glycosylation Nico Callewaert
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Glycobiology Session 4, slide 2 PAS staining for fungus detection in tissues Mechanism not exactly known
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Glycobiology Session 4, slide 3 Lectins: useful tools In clinical histology EY labs Sigma-Aldrich Calbiochem Note: lectins are normally available in substantial amounts, making the production of affinity columns possible. These affinity columns are extremely useful in the purification and fractionation of glycoconjugates. However, always keep in mind that you may be purifying a subpopulation of your molecule with lectin chromatography, as the sugar structures on any given glycosylation site are likely to be heterogenous.
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Glycobiology Session 4, slide 4 Structures of diagnostic relevance (see text)
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Glycobiology Session 4, slide 5 Lectin affinoforesis to detect glycoforms of tumor marker proteins. AFP-L3 for the diagnosis of HCC.
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Glycobiology Session 4, slide 6 Transferrin iso-electric focusing for the detection of Congenital Disorders of Glycosylation (in newborns) or for the detection of recent alcohol abuse (in adults)
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Glycobiology_Course_lesson_5 - Glycobiology Course IV...

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