263560DFd01 - association studies: illustration `A Genetic...

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association studies: illustration ‘A Genetic Risk Factor for Periodic Limb Movements in Sleep’ NEJM 2007;357:639-647 pathological fatigue nonrestorative sleep often: negative connotation sleep pathology sleep apnea myoclonus nocturnus (periodic limb movements) psychofysiological insomnia generally: sleep fragmentation
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multifactorial inheritance restless legs syndrome (RLS) uncomfortable and distressing sensory urge to move lower limbs ‘the most common disorder you have never heard of’ with or without perdiodic limb movements (PLM) involuntary, highly stereotypical, and regularly occurring limb movements ~every 20- 30s, ~¼ associated with ‘arousal’ genetic contribution: familial occurrence, ethnic disparity (5 to 15% in the populations of western European ancestry)
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multifactorial inheritance cases newspaper advertisement 451 individuals 514 first-degree relatives 965, of which 943 were evaluated RLS questionnaires (IRLSSG) PLM measurements controls individuals from other deCODE Genetics studies
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263560DFd01 - association studies: illustration `A Genetic...

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