case6 - Case 6 Elise De Smet Charlotte Gistelinck Tom Sante...

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Case 6 Elise De Smet Charlotte Gistelinck Tom Sante Jan Verplancke Katrien Verwaest
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Case 6 Pheochromocytoma A catecholamine roducing tumor producing tumor .
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Signs & symptoms - Excess release of catecholamines and high levels of circulating catecholamines - norepinephrine or epinephrine -> usually both - Rarely: dopa and/or dopamine leased intermittently and not continuously in most cases - released intermittently and not continuously in most cases - These secretions and the secretion pattern => responsible for the typical symptoms of feochromocytoma
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Typical symptoms - attacks characterized by: headache (50%), sweating (50%) and palpitations (50–60%) Also: pallor, anxiety, flank pain and skin sensations atecholamines vasoconstriction hypertension: - catecholamines -> vasoconstriction -> hypertension: 50 % of the patients have permanent hypertension, the other 50 % has paroxysmal hypertension - orthostatic hypotension (easier to detect than paroxysmal hypertension)
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Other symptoms: - Localized amyloid deposits found microscopically - Elevated blood glucose level: - Catecholamines -> lipolysis -> high levels of FFA --| glucose uptake (by muscle cells) - + beta-adrenergic receptors -> glycogenolysis and gluconeogenesis - weight loss - catecholamines --| peristalsis -> severe constipation, pseudo-obstruction or ileus - malignant pheochromocytomas : symptoms from tumor infiltration and distant metastases - Not all patients experience all of the signs and symptoms listed
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When? Family history
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This note was uploaded on 05/28/2010 for the course WE BIBI000000 taught by Professor Johangrooten during the Spring '10 term at Ghent University.

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case6 - Case 6 Elise De Smet Charlotte Gistelinck Tom Sante...

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