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Unformatted text preview: historical perspective Gene therapy comprises all therapeutic strategies in which host cells are genetically modified in order to obtain a therapeutic response. The idea of gene therapy is not new and can be perceived as a natural evolution of the developing opportunities of recombinant DNA technologies. As an illustration: before 1982, growth hormone extraction from the pituitary gland of 800 deceased individuals was necessary to treat 1 child with a growth hormone deficiency. Later on, a more safe treatment became available for more patients by the production of in vitro produced hormone, based on recombinant DNA technologies. In the future, gene therapy based approaches are expected to become feasible. Tin its developing years, the expectations for gene therapy were unrealistically high. The technology, however, could not be implemented easily. The fact that the expression of the transgene decreased relatively rapidly comprised one of the major problems in the introduction of gene therapy. Also, the concern of insertional mutagenesis caused major of the major problems in the introduction of gene therapy....
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This note was uploaded on 05/28/2010 for the course WE BIBI000000 taught by Professor Johangrooten during the Spring '10 term at Ghent University.
- Spring '10