F848A106d01 - cancer genetics cancer: always a genetic...

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Unformatted text preview: cancer genetics cancer: always a genetic disease, rarely heritable genetic analyses in cancer: s diagnosis s prognosis s treatment pathologies s hematological malignancies s soft tissues sarcomas s brain tumours, neuroblastoma s colorectal and lung cancer s breast cancer division, differentiation and apoptosis the hallmarks of cancer cancer is a multistep process hematological malignancies hematological malignancies: leukemias and lymphomas s leukemia: accumulation of blastic cells in the bone marrow s lymphoma: lymph node swelling leukemia: s chronic or acute s myeloid or lymphoid treatment s chemotherapy s bone marrow transplantation hematological malignancies myeloid: AML CML lymphoid: CLL ALL hematological malignancies treatment oncogenes & tumour suppressors cell division, differentiation & apoptosis s growth promoting & suppressing genes: oncogenes & tumor suppressors s essential to normal cellular development oncogenes in normal differentiation: Jekyll & Hyde chromosomal rearrangements s balanced: balanced translocation, inversion, insertion s unbalanced: unbalanced translocation, deletion, duplication the molecular cytogenetics of hematological malignancies the molecular cytogenetics of hematological malignancies...
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F848A106d01 - cancer genetics cancer: always a genetic...

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