CH2_handoutsinflammation

CH2_handoutsinflammation - Inflammation and repair AIM=...

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1 MPET-inflammation Inflammation and repair Stimulus (chemical, physical, microbial stress) Inflammatory response Repair MPET-inflammation AIM = homeostasis = destruction/encapsulation of the noxe and of the destroyed/damaged tissue = start of the repair process v replacement by the original tissue v replacement by fibrous tissue (scar) Inflammation = reaction of vascularized tissue to a damaging stimulus MPET-inflammation 5 cardinal signs of inflammation: (Celsus, 1 st century BC) # rubor redness vasodilation # calor heat # dolor pain mediators # tumor swelling extravasation of fluids Virchow # functio laesa loss of function MPET-inflammation 1793: Hunter: inflammation is not a disease but a non-specific reaction that is essentially beneficial No inflammation= no coping with infections, no wound healing BUT: inflammatory reactions can become harmful v systemic: sepsis v chronic stimulus v exaggerated reaction: anaphylaxis v “false”stimulus v scar tissues MPET-inflammation Protective mechanisms against potential deleterious effects of inflammation
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CH2_handoutsinflammation - Inflammation and repair AIM=...

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