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CH3A_slidesasthma - Asthma = a disorder of the airways...

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MPET-asthma Asthma = a disorder of the airways, characterised by a hyperreactivity of the airways to a variety of stimuli 2 main characteristics: reversible airway obstruction allergic inflammatory reaction
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MPET-asthma Clinic Attacks of dyspnoe and wheezing Episodic: exacerbations interspersed with symptom free periods Can lead to persistent disease (= status asthmaticus)
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MPET-asthma Epidemiology Prevalence: 10-15% of children, 5% of adults 1/3 emergency admissions in children Mortality: 0.3/100 000/yr, increasing INCREASING INCIDENCE: hypothesis housing (isolation, heated bedrooms) virus new chemicals, air pollution hygiene hypothesis
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MPET-asthma Etiology multifactorial: genetic and environmental components heterogenous
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