CH3A_slidesasthma - Asthma = a disorder of the airways,...

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MPET-asthma Asthma = a disorder of the airways, characterised by a hyperreactivity of the airways to a variety of stimuli 2 main characteristics: ü reversible airway obstruction ü allergic inflammatory reaction
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MPET-asthma Clinic ü Attacks of dyspnoe and wheezing ü Episodic: exacerbations interspersed with symptom free periods ü Can lead to persistent disease (= status asthmaticus)
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MPET-asthma Epidemiology ü Prevalence: 10-15% of children, 5% of adults ü 1/3 emergency admissions in children ü Mortality: 0.3/100 000/yr, increasing INCREASING INCIDENCE: hypothesis ü housing (isolation, heated bedrooms) ü virus ü new chemicals, air pollution ü hygiene hypothesis
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MPET-asthma Etiology ü multifactorial: genetic and environmental components ü heterogenous
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MPET-asthma Factors eliciting an attack ü Exercise: rapid breathing of dry cold air ü Infections ü Environment, pollution: ozone, sulphur dioxide, nitrogen dioxide ü Allergens ü Occupational hazards: dust, metal, solvent ü Drugs: aspirin
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This note was uploaded on 05/28/2010 for the course WE BIBI000000 taught by Professor Johangrooten during the Spring '10 term at Ghent University.

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CH3A_slidesasthma - Asthma = a disorder of the airways,...

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