CH3BhandoutsRASLIDES - Rheumatoid arthritis Rheumatoid...

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1 MPET-rheumatoid arthritis Rheumatoid arthritis Arthritis= inflammation of joints Rheumatoid arthritis= chronic multi-system disease of unknown origin Typical characteristic= : persistent inflammatory synovitis of the peripheral joints Destruction of cartilage Bone erosion Pannus formation Joint malformations Vigour, number of exacerbations, number of affected joints, response on therapy is heterogenous MPET-rheumatoid arthritis Rheumatoid arthritis Systemic involvement: Nodules Vasculitis Lung Prevalence : 1%, 3x higher in females MPET-rheumatoid arthritis Rheumatoid arthritis Cause= unknown Genetic factors: Relative risk= 4x higher in first degree relatives Monozygous twins: 30 % concordance Dizygous twins: 5 % concordance HLA-association: HLADR1,DR4 “shared epitope hypothesis” Link with infections ? Hormonal influence Reduction during pregnancy: clinical not histological Strand et al . Nature Reviews Drug Discovery 6 , 75–92 (January 2007) | doi:10.1038/nrd2196 MPET-rheumatoid arthritis
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This note was uploaded on 05/28/2010 for the course WE BIBI000000 taught by Professor Johangrooten during the Spring '10 term at Ghent University.

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CH3BhandoutsRASLIDES - Rheumatoid arthritis Rheumatoid...

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