CH6Aslidesmetabolic_syndrome_atherosclerosis

CH6Aslidesmetabolic_syndrome_atherosclerosis - METABOLIC...

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MPET Metabolic syndrome METABOLIC SYNDROME = CONCEPT, defined as syndrome of 5 components collaborating to promote diabetes and cardiovascular disease
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MPET Metabolic syndrome METABOLIC SYNDROME (1) degree of abdominal obesity (2) fasting or 2 hour postprandial glucose values (3) elevated average BP (4) decreased circulating HDL (5) high triglyceride levels
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MPET Metabolic syndrome METABOLIC SYNDROME abdominal fat as an endocrine organ FFA, cytokines, adipokines, angiotensin II adipokines: insulin resistance cytokines: (sub)inflammation damage of pancreas, hypertension, metabolic changes in muscle and liver
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Copyright ©2007 American Heart Association Opie, L. H. Circulation 2007;115:e32-e35 The diagnosis of metabolic syndrome requires a tape measure or accurate eye; fasting lipogram and plasma glucose measurements; and BP measurements
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MPET Metabolic syndrome METABOLIC SYNDROME therapy: lifestyle changes exercise weight reduction (Mediterranean) diet smoking cessation drugs???
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MPET Atherosclerosis ATHEROSCLEROSIS Arteriosclerosis= vascular stiffening =calcification of the media Atherosclerosis = inflammatory, fibro-proliferative disease of the intima
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MPET Atherosclerosis STRUCTURE OF THE NORMAL VESSEL WALL v INTIMA A single layer of endothelial cells Minimal subendothelial connective tissue Elastic fibers Lamina basalis TUNICA ELASTICA INTERNA
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MPET Atherosclerosis STRUCTURE OF THE NORMAL VESSEL WALL v MEDIA : smooth muscle cells
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CH6Aslidesmetabolic_syndrome_atherosclerosis - METABOLIC...

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