omics - BMC Medical Genomics Research article BioMed...

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Bio Med Central Page 1 of 35 (page number not for citation purposes) BMC Medical Genomics Open Access Research article The apoptotic machinery as a biological complex system: analysis of its omics and evolution, identification of candidate genes for fourteen major types of cancer, and experimental validation in CML and neuroblastoma Cinzia Di Pietro †1 , Marco Ragusa †1 , Davide Barbagallo 1 , Laura R Duro 1 , Maria R Guglielmino 1 , Alessandra Majorana 1 , Rosario Angelica 1 , Marina Scalia 1 , Luisa Statello 1 , Loredana Salito 1 , Luisa Tomasello 1 , Salvo Pernagallo 1 , Salvo Valenti 1 , Vito D'Agostino 1 , Patrizio Triberio 1 , Igor Tandurella 1 , Giuseppe A Palumbo 2 , Piera La Cava 2 , Viviana Cafiso 3 , Taschia Bertuccio 3 , Maria Santagati 3 , Giovanni Li Destri 4 , Salvatore Lanzafame 5 , Francesco Di Raimondo 2 , Stefania Stefani 3 , Bud Mishra 6 and Michele Purrello* 1 Address: 1 Dipartimento di Scienze BioMediche, Sezione di Biologia Generale, Biologia Cellulare, Genetica Molecolare G Sichel, Unità di Biologia Genomica e dei Sistemi Complessi, Genetica, Bioinformatica, Università di Catania, 95123 Catania, Italy, 2 Dipartimento di Scienze BioMediche, Sezione di Ematologia, Università di Catania, 95125 Catania, Italy, 3 Dipartimento di Scienze Ginecologiche e Microbiologiche, Università di Catania, 95125 Catania, Italy, 4 Dipartimento di Scienze Chirurgiche, Università di Catania, 95125 Catania, Italy, 5 Dipartimento di Anatomia, Patologia Diagnostica, Medicina Legale, Igiene e Sanità Pubblica, Università di Catania, 95125 Catania, Italy and 6 Courant Institute of Mathematical Sciences, New York University, New York, NY 10012, USA Email: Cinzia Di Pietro - [email protected]; Marco Ragusa - [email protected]; Davide Barbagallo - [email protected]; Laura R Duro - [email protected]; Maria R Guglielmino - [email protected]; Alessandra Majorana - [email protected]; Rosario Angelica - [email protected]; Marina Scalia - [email protected]; Luisa Statello - [email protected]; Loredana Salito - [email protected]; Luisa Tomasello - [email protected]; Salvo Pernagallo - [email protected]; Salvo Valenti - [email protected]; Vito D'Agostino - [email protected]; Patrizio Triberio - [email protected]; Igor Tandurella - [email protected]; Giuseppe A Palumbo - [email protected]; Piera La Cava - [email protected]; Viviana Cafiso - [email protected]; Taschia Bertuccio - [email protected]; Maria Santagati - [email protected]; Giovanni Li Destri - [email protected]; Salvatore Lanzafame - [email protected]; Francesco Di Raimondo - [email protected]; Stefania Stefani - [email protected]; Bud Mishra - [email protected]; Michele Purrello* - [email protected] * Corresponding author †Equal contributors Abstract Background: Apoptosis is a critical biological phenomenon, executed under the guidance of the Apoptotic Machinery (AM), which allows the physiologic elimination of terminally differentiated,
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This note was uploaded on 05/28/2010 for the course WE BIBI010000 taught by Professor Marnikvuylsteke during the Spring '10 term at Ghent University.

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omics - BMC Medical Genomics Research article BioMed...

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