elegans_networkbio

elegans_networkbio - C elegans network biology a beginning...

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* Edited by Jonathan Hodgkin. Last revised May 21, 2006. Published August 21, 2006. This chapter should be cited as: Piano, F., et al. C. elegans network biology: a beginning (August 21, 2006), WormBook , ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook. 1.118.1, http://www.wormbook.org . Copyright: © 2006 Fabio Piano, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. § To whom correspondence should be addressed. E-mail: [email protected] , [email protected] , [email protected] , or [email protected] dfci.harvard.edu . C. elegans network biology: a beginning * Table of Contents 1. Introduction . ........................................................................................................................... 2 2. Network components: transcriptome and ORFeome . ...................................................................... 2 2.1. Genomic databases . ....................................................................................................... 3 2.2. Computational predictions . ............................................................................................. 4 2.3. Transcriptome . ............................................................................................................. 4 2.4. ORFeome . ................................................................................................................... 4 3. Network connections: interactome . ............................................................................................. 6 4. Network perturbations: phenome . ............................................................................................... 7 4.1. Systematic phenomics . ................................................................................................... 7 5. Network dynamics: from transcriptome to localizome . .................................................................... 8 5.1. Dynamic transcriptome analyses . ..................................................................................... 8 5.2. In situ and in vivo analyses . ............................................................................................. 9 6. Network modeling: “omic” data integration . ............................................................................... 10 7. Perspectives . ......................................................................................................................... 11 8. Acknowledgments . ................................................................................................................ 12 9. References . ........................................................................................................................... 12 Abstract The architecture and dynamics of molecular networks can provide an understanding of complex
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elegans_networkbio - C elegans network biology a beginning...

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