Backup of bio lec 5(1) - In the name of ALLAH Biochemistry...

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1 In the name of ALLAH Biochemistry: 5/1/2009 Monday Quick Revision of yesterday lecture: Yesterday we have talk about signal molecule: - Glandular hormones production in glands and - A glandular or tissue hormones production in single cells. Another way of classification according to behavior in terms of Solubility 1- lipophilic mediators soluble more in hydrophobic environment 2- Hydrophilic) they are nice soluble in water, buffer. The exception is Echozanoid prostaglandins + leukotrine they don’t signals by intracellular receptors although they are very hydrophobic molecules they use G protein couple receptor signaling pathway. When IC receptor exists it acting finally in the cell nucleus and for example steroid can entered the cell easily through the lipids bilayer and excreted it’s actions in the nucleus. We have mem bound rece on the surface bind to the hydrophobic signal molecule
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1 This is now NEW:   Communication b/w cells how can cells now speak extracellularly with each other’s ( There are several situations). 1- Paracrine 2- endocrine 3- autocrine 4- Neuronal signal 1- Paracrine - This is a sender cell “green” the mediator producing cell (the single cell making the mediator cell). - The mediators secreted and “red” - Reaches the neighboring cells “yellow” for example a target cell which then expresses a receptor when this target cell is expected to response with different kind of biological activity (different gene expression …). - a way to reach a target cell in a far distance this could be just a mixture of cell “ that express the rece for this signal - In some organs like liver have phagocytes, monocytes and some other cells. (b) juxtakrin (e) neuronal (a) parakrin Zielzelle Zielzelle Zielzelle Neuron Axon Synapse Neurotransmitter (d) autokrin (c) endokrin Zielzelle Blut
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1 1. The monocyte produce inflammatory mediators ILI, TNF, … are secreted by the monocyte in the liver - A typical Eg the monocyte in the liver : they secrete mediators which directly act on the neighboring cell mainly a hepatocyte for instance which express rece and this happen also in the intestinal tract So these mediators produced by cells let say in the liver by microphages or also microphages in the intestinal tract. These mediators they are release and immediately act on the neighboring cells and these mediators are not stored in a gland and therefore they are not called hormones but we can call it Tissue hormones. a special type of paracrine - we can have a neighboring cell which can be stimulated by a special type of stimulator jexacribe - compare to 1. the mediators producing cell which secrete soluble mediators which can spread every where, 2. where in the jexacrine you have a mem bound ligand and this ligand is fixed in the cell so to act on the rece this need a close contact 2 -Endocrine : - In Order to get a much bigger distance let said two medias you may able to get
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Backup of bio lec 5(1) - In the name of ALLAH Biochemistry...

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