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Backup of biocek(1) - In the name of ALLAH Biochemistry LEC...

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9 COO NH 3 M1 M2 M3 M4 α α β δ γ + - In the name of ALLAH Biochemistry LEC 6-1-2009 Tuesday Yesterday Topic was about receptors Receptors activation occurs coordinate sequential ligand binding to the individual receptors subunits , high affinity receptors complex formation and the receptor can forms dimmers, trimmers , tetramers and hexamers Eg the insulin receptor makes dimmers conformational changes and orientation changes which can observe after the ligand binding Type of receptors 1- G ptn coupled receptors 2- Tyrosine kinase receptor. 3- Tyrosine kinase associated receptors and 4- nuclear receptors Slid 4: principle of signal transductions - you have ligand dependent ion channels only when the ligand in this cases Ach is bounded to this complex receptor , only if this ligand bound to these 5 subunits and each of the 5 subunits is composed of these 4 helices called m 1 ,m 2 ,m 3 , m 4 . It is 20 subunit “transmem domain” in total then upon ligand binding a conf changes in the m 2 helix then the channel open  DR: Mesho_0
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9 Slid 5: Nuclear receptor o we have a ligand which enter the cell meets inactive receptor (nuclear receptor) not membrane bound. o this rece is inactivated by the HSP which seem to cover the NLS o when it is dissociates upon ligand binding leaving this complex o the nuclear localization signal become exposed and o then the complex of ligand and nuclear receptor can move into the nucleus and bind to response elements in promoter or enhancer regions of target gens Slid 6: This is the G ptn coupled receptor principle The principles is That there is exchange of GDP by GTP in the G ptn .  DR: Mesho_0
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9 G ptn is needed by 7TM receptor. - G ptn consist of 3 subunits α, β and γ - The G ptn are anchored in the membrane by lipid long chain residues . - The α GDP form is the inactive G ptn form - if it is exchanged by GTP then the dissociation of the trimmeric G ptn in α, and βγ subunits.occurs - Mostly the α subunits loaded with GTP can find effectors ptn like phospholipase and adenylatecyclease. - then you initiate a completely a kind of destined signaling pathway - The principle is that this exchange of GDP by GTP occurs.
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