bio chem lec 19 - 1 In the name of ALLAH Bio chem. 19.1 TNF...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
1
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
In the name of ALLAH Bio chem. 19.1 TNF A target of the TNF and IL-1 and other interleukin the activation of the TF NF-kB which is impo in the inflammatory diseases TNF : is a cytokines a pro-inflammatory cytokines NOTE - the cytokines can be divided into o pro-inflammatory Eg IL-1 and TNFα and IFN β mean If you inject an animal with these it will induce fever o anti-inflammatory : to neutralize and neutralize inflammation o as well as cytokines which has both prosperities according to the cell type Eg IL-6 where pro-inflammatory cytokines are generated ??? - mainly in monocyte : if you treat them with lipopolysaccaride “LPS” which is a component from bacteria found b/w the cell wall and the plasma mem it can enormously stimulate the monocyte “Mp” o which is the pro-inflammatory producing cell when it is stimulated including TNF - then it could be T-cell, mast cell the TNF : have a relatively high molecular mass “MM” TNF it self is small molecule MM of 17,000 D but it run as a trimmer 51,000 D The TNF rece also form a trimmer Slide 3 - we have a TNF producing cell o which have a mem bound form of the TNF so it is synthesis but not secreted as soluble ptn but it anchored on the mem instead so there is a mem bound TNF : and this is impo in the cancer 2
Background image of page 2
o but the cell have an enz TACE “TNF α converting enz” = ADAM and this is a metaloprotease “mem bound” which makes a limited protyolsis this is the enz which convert the mem bound TNF into soluble form and the TNF is a trimmer - we have tow kind of rece o The soluble TNFα and the mem bound form can act on TNF RI with a MM 55 Leads to apoptosis : here you activate the caspases “this is
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 05/29/2010 for the course MEDICEN 2100 taught by Professor Saba during the Spring '10 term at Columbia State Community College.

Page1 / 6

bio chem lec 19 - 1 In the name of ALLAH Bio chem. 19.1 TNF...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online