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bio lec 13.1 - Bio done by mesho 13.1 Tuesday Yesterday we...

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1 Bio done by mesho 13.1 Tuesday Yesterday we stop at Phospholipase C. phospholipase C generate the: 1- Calcium (Ca 2 ) 2- Diacylglycerol (DAG). Calcium (Ca 2 ) and Diacylglycerol (DAG) are second messenger , and these second messenger molecules are very important for activation of protein kinase C. Protein kinase C It is in the cytoplasm it is recruited to the membrane upon activation and what you need for that is DAG and Ca 2 the activation of protein kinase C at the cell membrane. Protein kinase C comes in inactive formed , Protein kinase C consist of: 1-Regulatory part. : is the green part 2- Catalytic part.: the blue Steps - The Ca 2 bind to the regulatory part. - The Phosphatidylserine (PS) is involved binding. - Diacylglycerol (DAG) has also a binding site. - This is called here (PSR) Pseudosubstrate region . - then is C2, C1A,B this part is important for interaction with a membrane And if this occurs the molecule become active. it’s recruited in it’s inactive form and then the active part is released PKC activation required DAG and Ca 2 PKC play an important role in 1- regulation of growth 2- differentiation as well as 3- in tumorigenesis. - Tumors start to develop when PKC is active. PKC is stand for Calcium . Dr:Mesho-0 Ca 2+ DAG PS aktiv inaktiv C2 C2 C1A,B C1A,B PSR PSR
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2 Now this is a big family of more than 12 members and it is subdivided into conventional PKC .This is the Ca 2 activated and new PKCs and conventional PKCs. Receptor with intrinsic Tyrosine kinase activity or enzyme activity. the members we discussed all have intrinsic kinase activity and we have - one example for serene kinase TGF β two examples at least for tyrosine intrinsic (Tyrosine kinase) insulin receptor and PDGF receptor. Extrinsic kinase activity - Which mean the receptor is dimerising when the ligand binds and - associated kinase is activated but this not an intrinsic kinase.it is recruited although it is very tightly recruited. - This system signals as good as intrinsic (Tyrosine kinase) - The typical example of this group of cytokine interleukin group of receptors. The acute phase response to injuring infection - If our body is hurt by tissue injure by trauma infection, growth of tumor, infection by bacteria or viruses by car accident then - then our body react with an acute inflammatory accident that’s a local reaction which means the blood cell manily monocyte and granulocyte, lymphocyte, thrombocyte are activated also tissue cells become activated. - e.g. .if you are bitten by mosquito you get this kind of defence reaction initiated and also tissue cells are involved like macrophages mast cells , lymphocyte. Dr:Mesho-0
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3 - These Activated cells they synthesize and secret inflammatory mediated Eg histamine which is the responsible molecule in allergic reaction and there are many anti-histamincal around.
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