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bio lec 14.1(1) - In the name of ALLAH Biochemistry 4.1...

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1 In the name of ALLAH Biochemistry 4.1 Sunday Slid 1: The signal transduction is important because any hormones any interleukin any chemokine can exert signal without going with it information to the cell nucleus. In signal transduction the first thing: (1) Introduction to communication And then (2) Signal molecules what are molecules which are able to exert signal on a target cell. And then (3) Receptors this are the mediators of the signal and in the inner part of the target cell. And they are quite many with diff kind , The biggest class of receptor is the G-ptn Couple receptors “Eg smelling rece” a. They are pharmacologically important the receptors, if you block the receptor you block the signaling cascade. (4) Signal transduction of membrane-bound receptors so this is complicated pathway, how the signal finally comes let’s say: from the plasma membrane, from the cell surface to the cell nucleus. Therapy is depending on the knowledge of the signal pathway, lets say: - inhibit the signaling cascade at the very top then it can’t happen - If the signaling pathway kind of spreads and then cme to the place where the signal exert it action then you have a nice inhibitor.  DR: Mesho_0
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1 Slide 2: (1) Introduction to communication: The Communication between cells of multicultural organisms is very important. The simplest communication is the α factor discovered in yeast - When α cells and a cells - a cells secrete α factor which act on the a cells and then kinds of prolif. Occur This is the simplest kind of communication b/w tow types of cell and they are the yeast cell in our more complicated system where we have organs (brain, kidney, liver). It is more complicated Slide 3: We start with the definition of the communication In a general is a tell communication your telephone, email, net. 1. Signal emission 2. Signal reception 3. Signal transmission 4. Signal decoding 5. Signal processing. And this is if you have a telephone as a simple system. And in biology I have 1. Stimulation 2. Reception 3. Signal transduction 4. Signal transformation  DR: Mesho_0
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1 5. Biological response. It corresponding to the signal processing Slide 4: Communication in an organism can be either extracellular or intracellular or both.
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