bio lec - Bio chem lec 11.1 - - The insulin rece a receptor...

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Bio chem lec 11.1 The insulin rece - a receptor activation - you have to get a signal, let say final through the nucleotide where you can change the gene expression ,migration ,and impo physiological …, - so an active insulin receptor recruits after being tyrosine phosphrate on the cytoplasmic tails o Insulin receptor substrate and this called adaptor molecules - And insulin receptor substrate then lead to the o activation of a signaling cascade which called Mitogen-Activated Protein Kinase cascade which end in gene expression o The other one is Phosphoinositide-3 kinase cascade. These are 2 different cascades activated after insulin receptor activation and this mediated via these insulin receptor substrate, there are 4 isoforms but isoforms no. 3 is not if interest in the humeral system Insulin 1- is a ligand 2- consist of 2 chains A chain, B chain they are connected by S-S bridges 3- the insulin rece consist of dimmer of dimmer {green & light green} 4- tyrosine kinase receptor when they want to become active they always have to dimerize . such tyrosine kinase receptor like an insulin receptor can do many things and these 2 cascade activation they are not independently activated .and there is a cross talk the PIP3 kinase cascade is more complicated than the RAS-RAF- MEK-MAPKinase , The link always goes from the receptor to the adaptor enzyme in this case called PI3Kinase - And PI3Kinase consist of 2 subunit: o p85 & p110 one is a regulatory and the other catalytic active subunit. - And PI3Kinase synthesize from phosphoinizetol 4,5-diphosphste( PI4,5-P2 ) 1
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PDGF signaling - PDGF growth factor it is active form act as homo. Or heterodimer - PDGF has 2 different receptors types and 3 possible forms o Receptor α chain & receptor β chain they have intrinsic Tyr kinase domain which autophosphorelate each other and
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This note was uploaded on 05/29/2010 for the course MEDICEN 2100 taught by Professor Saba during the Spring '10 term at Columbia State Community College.

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bio lec - Bio chem lec 11.1 - - The insulin rece a receptor...

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