bio lec 14.10 - Biochemistry Tuesday The nuc mito...

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Biochemistry Tuesday, October 14, 2008 The nuc, mito, chloroplast : are bounded by 2 bilayer mem The intermembrane space in the mito : this space accumulate proton it is very acidic place, and this acidity correlated to the synthesis of the ATP The plasma mem is a permeability barrier it separate the outside of the cell to the inside of the cell for Eg our skin, so we can keep the inside condition which are quite different from he outside, that this is possible is due to a lot of different molecule which are integer part of this plasma mem “channels, pumps, …” form a lot of this plasma mem ptn and they are anchoring points for the MF and IF and thick tubulin fil and .therefore they are the point where movement can go on Plasma mem can form a Mvili single one which attach some where here and then the rest of the body can be drown to this place and then the next pseudopodia is out in the space look for a place to attach and then the cell can move from one place to the other All this the function of the plasma mem Endosome : are internalized plasma mem and are the carrier molecule for caring out or in certain substance coat differently as they are but this is essentially an invagination or a fusion of vesicle from these endosome Lysosome : these are the internal digesting tract for the cell they contain a lot of hydrolytic enz which can split lipid and nucleic acid and CHO if one of these enz is missing you are in very difficult disease state One dis is Pumpes disease : it is missing glycosidase which split polyscc, so what happen is that polyscc accumulate in the Ly and they go bigger and finally is disrupt, what happen that all this digestive enz are free in the cytosol and they begin to digest this disasters you can’t easily imagine Peroxisome : are usin O as oxidant, they are simply destroying molecule by oxidation them, not like mito the proxi don’t produce ATP they have only a single mem but they can produce smaller molecule which are able to be use for synthesis for Eg acetyl CoA which use as the starting substance for synthesis cholesterol and steroid Ptn synthesis : goes on in the cytosol without any mem, and goes on the RER, these ptn are synthesis in the lumen of the RER, they don’t appear in the cytosol and if they are pinch of then packaged and sorted in the Golgi then they can brought to be exported and this is impo mechanism For Eg for the synthesis of hormone like insulin 1
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which are present underneath the plasma mem in small vesicle and if the signal comes they fuse with the plasma mem and release the insulin The nuc : the house of the genome all the DNA and surrounded by a double mem which has a nuclear pores, the nuclear pore composed of about 50 different ptn which allow a very specific transport of these molecule which have to go out or into the nucleus The chloroplast : they are specific organelles in the plant cells, they are the bases of our live bec they produce all the O which we are breathing they have evolved a little
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bio lec 14.10 - Biochemistry Tuesday The nuc mito...

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