bio lec 1-11 part 1 - Bio sat 1.11 Intracellular Transport...

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Bio sat 1.11 Intracellular Transport Eu caryotic cells are highly organized structures. Biochemical reactions are located in specific structures, since they work in parallel and have thus to be compartmentalized. Transport of large molecules like proteins and nucleic acids has therefore to be controlled and organized in a specific way for proper function of the cell. The impact of transport processes for medicine is reflected by the finding, that defects in transport components might lead to severe diseases . Examples are i.e. lysosomal storage diseases which might lead to neurological disorders. How the transport of large‘ molecules is controlled by the cell depends on the compartment. 1
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DNA transcription mRNA translated to ptn which have to transported out the nuc Nuclear transport The nucleus is structured. In ( a ) the nucleus is stained by specific dyes : green chromatin “DNA + ptn” , red ribonucleoproteins, which are part of the splicesosomes . The nucleoli are not stained. ( b ) Staining of methylated Histone 3 ( green ) and DNA rich areas ( red ). 2
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- in the nuc we have the nucluosome where the ribosoms are made, and the ribosomes is a big aggregation of molecule which should export to the outside for the translation mechanism - for the transcription and splicing they have to import ptn The nuclear envelope is made of the endoplasmic reticulum ( ER ). It is therefore not a single membrane, but made of the inner AND outer ER membrane . Large molecules pass through this barrier from the cytosol using pores in the envelope. However, these nuclear pores are not simply ‚wholes‘ in the nuclear envelope, but highly selective controls of the nuclear transport . The nuclear pores are controlled by the nuclear pore complex (NPC) .”it is fixed in the mem/; The nuclear pore complex ( NPC ) is composed of about 20 different proteins 3
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and has a molecular mass of about 125 mio. daltons. It controls the export and import of large molecules . A typical nucleus contains 3.000- 4.000 NPC . 500 molecules can be transported by a single NPC per second in either direction . How this is managed by the
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bio lec 1-11 part 1 - Bio sat 1.11 Intracellular Transport...

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