bio lec -1-11 part 2 - Pag 6 The splicing We some time...

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Pag 6 The splicing We some time observe splicing defects so in molecular genetics the splicing events is very impo If you skip one nuclutide in the mRNA in the primary transcript you will have severe changes on the ptn which might cause genetic diseases What kind of the ptn have to be transported into the nuc ???? The NLC is shown in an experiment if you have T antigen with the normal NLC you find most of this ptn which is labeled in the nuc “mean they can enter” if you skipped just one aa most of the ptn will found outside the nuc so the import is not possible any more A single aa is sufficient to block the import into the cell this mean the import signal is very specific transport it is impo that the transport is posttranslational Eg : the ER cotranslational process Scrapy : which is a ptn has a wrong conf lead to a sever disease so the folding of the ptn is impo one aspect is that the ptn is not transported by it self into the nuc but it need a cargo receptor so it need a receptor and binding to this rece lead
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bio lec -1-11 part 2 - Pag 6 The splicing We some time...

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