bio lec teus 4.11 part 1 - Teus 4.11 There are no...

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Teus 4.11 There are no differences between ER bound and free ribosomes in a cell All ribosomes are derived from the same cytosolic pool ( A ) . There are no differences between cytoplasmic of ER-bound ribosomes . One mRNA keeps at the ER-membrane and fixes a number of ribosomes to its surface. These aggregates are called polyribosomes ( B ). In ( B ) some of areas are cut in the plane of the ER membrane. Thus the ribosomes appear to be oriented in a rosette like structure. The translocator is a membrane protein forming a water filled pore. The core complex is called Sec61 1
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The core complex of the translocator is the Sec61 complex ( A ) . It forms 1. ) a pore and 2. ) a seam, which allows the release of the protein to the membrane ( B ) . Sec61 forms an alpha helix , which acts as a plug for closing the pore ( A ). The translocator is a membrane protein forming a water filled pore. The core complex is called Sec61 Four Sec61 complexes ( B ) are thought to form the translocator ( A & B ). The brawn dots in figure ( B ) indicate the attachment sites of the ribosome at the Sec61 complex . The ring indicates the position of the exit site of the large ribosomal subunit. It is not
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