bio lec teus 4.11 part 2 - If the SRP fail to block the...

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If the SRP fail to block the translation may be the peptide chain s coming out the ribosomal subunit and doesn’t go to the lumen of the ER but remain in the cytoplasm and the cell will destroy it self so this block is a security device The SRP has 2 function - recognition of the signal sequence - blocking the translation process - and then binding the complex to the rece on the surface of the ER at the end : we need - a signal sequence - we need SRP - and w put them on the translpcator page 2 - in the center we have α helical structure - Sec 61 has 2 function o It has to build up a pore so that the ptn gets through the mem o Some ptn have to be release to the mem so there is seam on this molecule which can open laterally - When the Sec61 is not connected to the ribosome it kept closed by the mem ptn - The Transloctaor have an area where the peptide run through and the signal sequence is holed and fixed by the seam of the Sec61 of the molecule 1
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Page 4 - again signal seq it is fixed to the translocator again
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This note was uploaded on 05/30/2010 for the course MEDICEN 2100 taught by Professor Saba during the Spring '10 term at Columbia State Community College.

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bio lec teus 4.11 part 2 - If the SRP fail to block the...

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