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Unformatted text preview: this phosphate group from this TF which makes the nuclear import signal available What kind of the drug are acting in a similar way to the cyclosporine ??? mean it act on the nuclear rece ??? If you confronted with patient which has asthma by give 2 agonist which have the 7TM rece as a target and catecholamine rece So the 2 agonist on the sm m lead to the relaxation so you rapidly have the access to relax the constriction of the lung vessels What about cortizol ???-it take times bec it work on the transcription level and the rece for it is also a TF which need to be transported in the nuc so the drugs acting on that way are slow acting drugs What are the other Eg ??? - cortizol - steroid hormone -so they are ligand of a ptn IC ptn-And then the ptn coupled to the ligand and change its shape which is then fits to the cargo rece -The cargo rece is transported through the NPC into the nuc...
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- Spring '10