Bio done by Huda the first part from 1till 20 10-11-2008

Bio done by Huda the first part from 1till 20 10-11-2008 -...

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Bio done by Huda the first part from 1-till 20:00 after me masha3el 10-11-2008 We look for the transport process; we focus in the last lecture on the process going on b/w the ER on …golgi apparatus, basically we started to identify how this process are done, how these are getting specifically managed in a cell? So we have seen that G ptn again play an important role for this process to pill up a COPII coated vesicle for instance, these COPII coated vesicle are similar to the clathrin vesicle from they are contain other ptn of the surface of the vesicle, and we have learned that these vesicle needly structure because they contain specific material and this is the kind of … which the vesicle needs to low specific cargo into the lumen of the vesicle and to transport the vesicle to the certain destination. So to … that Gptn we have learned also very important because for the cell of course it important to know where from this ER patch and these formation of these coat ptn, and the vesicle has to be formed. And once …mechanism we have to identify …the GEF and Sar 1-GEF is needed which is catalyzing the exchange of the GDP instead of the for GTP at this small G ptn. And then what we have see here is an amphipathic helix is opening out of molecule and having…. This…and outer leaflet of the outer membrane.
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So the conformational change which is induced by exchange GDP against GTP leads to changes of the property of this molecule which have to anchor this here. And then this is used to connect other ptn on the surface and these coat ptn of COPs are also recognizing the cytoplasmic tail of cargo receptor which fixes again on the inner part a certain cargo and then we have seen this is a specific process in a way which cannot help or understand how the cell manage can … to transport a certain cargo …destination. So then we have seen that this curve chain in the membrane and this is induced by forming this patch and we have also seen that other ptn and also necessary and this is a cooperative step I told you the Phosphoinosetile and the recognition of the phosphinosetile to the certain membrane are also very important for the formation and the assembly of all these ptn on the surface and then the vesicle is formed. So what we have also seen has G ptn are also necessary when the vesicle already formed, now we have the task how gets the vesicle to certain destination, how do we know where this vesicle belong to formed? And one … that this family here the rapidly … they comprise one of the largest family of small G ptn and then this G ptn had to specifically identify target membrane.
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So how does Rab-GTP help us to transport the ptn into the target membrane. So what we know today is, here is the cargo receptor, the cargo again the V-SNARE and the Rab-GTP, and what we have learn this that Rab-GTP is recognize by some Rab effector ptn on the a surface of this target receptor so
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This note was uploaded on 05/30/2010 for the course MEDICEN 2100 taught by Professor Saba during the Spring '10 term at Columbia State Community College.

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Bio done by Huda the first part from 1till 20 10-11-2008 -...

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