bio lec - 16.11 - Sun 16.11.2008 The repetition - for the...

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Sun 16.11.2008 The repetition - for the regulated exocytosis process a special kind of vesicle the secretory v has been formed which bud from the Golgi and have diff prosperities from M6P “they differed in that in the secretory v the cargo has to be concentrated bec we have to have huge amount of molecule in these v” - and these v store and upon the signal they release there content - So in these process there is certain regulation o To conc and bring all these material on the secretory v “ o may be fusing of some v lead to inc the material inside the vesicle but also lead to enlargement and in order to conc this reduction of the surface mem is needed o this done by the retrieval pathway in a clathrin coat to bring back the PL was used to form this v o so the result dense material loaded by the vesicle - some time from the same ptn different peptide can be cleave off and this cleavage process is a maturation process which is going on the ER and Golgi - and the protease which needed for that are expressed in a specific way but they all cleave the same precursor ptn into different part according to the need of the cell where they are A specific exo are in the n cell which is a polarized cell - the vesicle in the nerve are transported first from the golgi to the synapse - and then stored there to delivered the material to the synaptic cleft - this mean they kept in hold, where the tetra helical conformation is occurng only when there is signal - the signal for the mast is the antigen which bind to the IgE and 1 IgE bind to the mast and the signal is transported to the inner part of the cell - if the is only release of vesicle without endocytosis this will lead to the swelling of the cell 1
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- where the surface mem have to be regulated by vesicular transport export and import “wound repair – phagocytosis - cleavage furrow” - tight J is a cell cell contact structure - in the n. cell the axon hillock “part of the mem which separate the cell” - the ectoderum layer during the embryonic development is used to for the NS how the cell manage the transportion of vesicle ??? - the GPI are rich in the apical mem in the endothelial - glycol mean that there is sugar residue come to the PL to protect the surface from the enz present in the surrounding So the transport can be - directly or indirectly - the secretory pathway “directly” to the basolateral hen the endosome is used to put again the endosomal and then directly to the apical one feature directing cell to the apical mem ???? these GPI anchors which is formed in the ER lumen tropanosomes they regulate there surface coat by cleaving this PL by the Plipases in the apical mem these anchors are also used by the secretory ptn so the ptn with this linkage or have this linkage they form some aggregate in the certain lipid which form a lipid raft “kind of Inland which have certain composition of the lipid” the ptn with this anchor tend to associate with this lipid rafts so the
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This note was uploaded on 05/30/2010 for the course MEDICEN 2100 taught by Professor Saba during the Spring '10 term at Columbia State Community College.

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bio lec - 16.11 - Sun 16.11.2008 The repetition - for the...

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