Biochemistry_REP - 1 Biochemistry Wednesday, November 12,...

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Biochemistry Wednesday, November 12, 2008 Q1/ Explain the import process at the endoplasmic reticulum? SRP cycle. SRP Signal-recognition particle. SRP The signal recognition particle (SRP) is aribonucleoprotein (protein-RNA complex) that recognizes and transports specific proteins to the endoplasmic reticulum in eukaryotes and the plasma membrane in prokaryotes . Maha said: 1- The SRP which found in the cytosol. In eukaryotes, it binds to the endoplasmic reticulum signal sequence. 1
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Prof said: How does the cell know that the protein has to be secreted furnaces? Signal sequence ER signal sequence: Typically 15-30 amino acids Consist of three domains: a positively charged N-terminal region, a central hydrophobic region, and a polar region adjoining the site where cleavage from the mature protein will take place. A signal sequence on nascent secretary proteins targets them to the ER and is then cleaved off and this will bind to the SRP. And what is this SRP? SRP The signal recognition particle (SRP) is a complex riboprotein. It contains a single small RNA-molecule and six different peptide chains. And six different polypeptides complexed with a 300-nucleotide (7S) molecule of RNA. What are the functions of SRP?
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This note was uploaded on 05/30/2010 for the course MEDICEN 2100 taught by Professor Saba during the Spring '10 term at Columbia State Community College.

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Biochemistry_REP - 1 Biochemistry Wednesday, November 12,...

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