Lecture4 - Lecture 4 4/8/10 Background reading: 5th Edition...

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Lecture 4 4/8/10 Background reading: 5 th Edition – Chapter 11: pages 651-675; 680-687 4 th Edition – Chapter 11: pages 615–637; 643-649 Transit of Small Molecules across Membranes: Membrane potential Ion channels Ionophores Passive transport Carrier proteins Active transport
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Membrane Potential Difference in electrical charge between two sides of a membrane creates a membrane potential. Comparison of Ion Concentrations Inside and Outside Cell Component Inside (mM) Outside mM) Cations: Na + 5 – 15 145 K + 140 5 Ca 2+ 10 -4 1 –2 H + 7x10 -5 4x10 -5 (pH 7.2) (pH 7.4) Anions: Cl - 5 –15 110 Organic 138 9
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Construct two compartments separated by a black membrane: Electrodes 150 mM NaCl 150 mM KCl Black membrane No electrical potential across above membrane since it is impermeable to ions and the concentrations on each side would be maintained. Membranes allow selective movement of ions through specific channels created by proteins in the membrane.
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The K + leak channel allows K
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Lecture4 - Lecture 4 4/8/10 Background reading: 5th Edition...

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