Lecture5 - Lecture 5 4/13/10 Background reading: MBOC 5th...

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Lecture 5 4/13/10 Background reading: MBOC 5 th Edition: Chapter 12: pages 695-704; 723-745 MBOC 4 th Edition: Chapter 12: pages 659 - 669; 689 - 710 Outline: Organelle topography Membrane synthesis Targeting of proteins to intracellular destinations Transmembrane transport In vitro translocation Signals
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Organelle topography Eukaryotic cells have membranous compartments - organelles
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Hypothetical scheme for evolutionary origin of nucleus:
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Hypothetical scheme for origin of mitochondria and plastids:
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Topographical relationships among compartments of cell: Cytosol is a reducing environment Outside of cell is an oxidizing environment.
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Membrane Synthesis Most lipid bilayers are assembled in the endoplasmic reticulum (ER).
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Phospholipid synthesis occurs in cytosolic leaflet of the ER.
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Phospholipid exchange proteins carry phospholipids between organelles.
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Targeting of proteins to intracellular destinations Targeting of Proteins to intracellular destinations Problem: Average eukaryotic cell synthesizes 1,000 – 10,000 different proteins.
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This note was uploaded on 05/30/2010 for the course BIS BIS 104 taught by Professor Privalsky during the Spring '09 term at UC Davis.

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Lecture5 - Lecture 5 4/13/10 Background reading: MBOC 5th...

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