Lecture6 - Lecture 6 Background reading MBOC 5th Edition...

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Lecture 6 4/15/10 Background reading: MBOC 5 th Edition: Chapter 12: Pages 704 – 723, 736-737 4 th Edition: Chapter 12: pages 669 – 689, 698-703 Outline: Targeting and transfer of proteins to intracellular destinations Transmembrane proteins Signals Protein transit to mitochondria and chloroplasts Chaperones Gated transport Nuclear lamina Co- and post-translational modifications of proteins in ER
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Proteins destined for nucleus, mitochondria, peroxisomes, plastids and ER must transit across membrane. Proteins destined for all other organelles and for cell surface and cell exterior must first enter ER and then move on.
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After translocation of a soluble protein through the ER membrane its signal sequence is removed by a signal peptidase. Figure 12-45 Molecular Biology of the Cell (© Garland Science 2008)
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Transmembrane proteins Transmembrane proteins contain stop-transfer signals that anchor that portion of the protein in the membrane. Example of how a single-pass transmembrane protein with a cleavable ER signal sequence is anchored in the membrane.
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Some transmembrane proteins have signal sequences that are located some distance from the NH 2 -terminus.
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Depending on the sequence flanking the signal, the protein is inserted either as shown in the previous slide or a below.
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Some transmembrane proteins have several start signal and stop signal sequences.
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This note was uploaded on 05/30/2010 for the course BIS BIS 104 taught by Professor Privalsky during the Spring '09 term at UC Davis.

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Lecture6 - Lecture 6 Background reading MBOC 5th Edition...

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