Lecture8 - Lecture 8 4/22/10 Background reading: MBOC 5th...

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Lecture 8 4/22/10 Background reading: MBOC 5 th Edition: Chapter 13: pages 779-787; 791-795; 800-807 MBOC 4 th Edition: Chapter 13: pages 746-753; 755-763; Outline: Regulated secretion Constitutive secretory pathway Endocytic pathway Receptor-mediated endocytosis Polarized cells Vesicular transport
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Regulated Secretion Some cells are specialized to carry out the regulated secretion of secretory proteins only in response to a specific signal. The cell stores these proteins in special secretory vesicles in the cytosol until needed.
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Constitutive secretory pathway This appears to be a non-selective pathway that targets proteins and lipids in the ER that are not destined for other locations to the Golgi and then to the exterior of the cell. It is often called the Default pathway .
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Three best-understood pathways of protein sorting in trans Golgi network: The three best-understood pathways of sorting in the trans -Golgi
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Endocytic Pathway Leads inward from the secretory pathway Vesicular transport carries glycoproteins through this system and they can undergo various modifications as they proceed through different compartments. Closely linked with the secretory system
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This note was uploaded on 05/30/2010 for the course BIS BIS 104 taught by Professor Privalsky during the Spring '09 term at UC Davis.

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Lecture8 - Lecture 8 4/22/10 Background reading: MBOC 5th...

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