Lecture11 - Lecture 11 5/11/10 Outline Cell shape and...

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Unformatted text preview: Lecture 11 5/11/10 Outline Cell shape and motility Organization of actin filaments Myosins Cell signaling Overview of signal transduction Cell surface receptors G protein-linked receptors Trimeric G proteins Family of subunits Background reading: MBOC 5th edition: Chapter 16: Pages 992 1000 Pages 1006 -1019 Chapter 15: Pages 879-886; 904-921 MBOC 4th edition: Chapter 16: Pages 929 936 Pages 949 959 Chapter 15: Pages 831-836; 852-871 Cell shape and motility Fibroblasts migrate in the extracellular matrix and will also move if plated out on an appropriate substratum. Protrusion of a leading edge Newly polymerized actin is shown in red. Focal contacts form: Organization of actin filaments Actin arrays in a cell Bundles Web-like networks Array of actin filament formation is accomplished by a variety of different types of proteins that can bind to actin: 1) Capping proteins - can bind to and stabilize actin filament at + end II. Cross-linking proteins- organize different assemblies of actin filaments: Two types: 1) Bundling proteins - cross-link actin filaments into parallel arrays Examples: a) fimbrin Microvillus Intestinal epithelial cell b) -actinin: Thin filaments are actin filaments Muscle cells 2) Gel-forming proteins Example: Filamin yosins Motor proteins for actin filaments hydrolysis...
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Lecture11 - Lecture 11 5/11/10 Outline Cell shape and...

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