Lecture12 - Lecture 12 5/13/10 Background reading: MBOC 5th...

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Lecture 12 5/13/10 Background reading: MBOC 5 th Edition: Chapter 15: pages 921 - 926 MBOC 4 th Edition: Chapter 15: pages 871 – 876 Outline: Family of α subunits G S G olf G t Gq Inositol Phospholipid Pathway IP 3 Diacylglycerol Enzyme-linked receptors Receptor tyrosine kinases SH 2 and SH 3 domains
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Had been considering G protein-mediated signal transduction. The G protein is the transducer which relays the information that the signal has bound to the receptor across the membrane to the primary intracellular target. The primary target is either a protein that can change the concentration of a second messenger or that can act as an ion channel. - signal receptor transducer intracellular target
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Family of α subunits ¾ 20 identified Many different receptors can interact with them Can bind to same βγ subunits. Thus, different receptors bind to selected types of α subunits and lead to different responses. Will now consider examples of signal transduction with various α subunits: G S G S subunit : acts as accelerator and activates adenylate cyclase. adenylate cyclase is thus the primary target and cyclic AMP (cAMP) is produced.
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In most animal cells cAMP exerts its effect by activating cAMP-dependent protein kinase, called protein kinase A (PKA). Ed Krebs – received Nobel prize for discovering this activation.
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Substrates for PKA differ in different cell types: Skeletal muscle cells: PKA phosphorylates enzymes involved in glycogen breakdown Signal = adrenalin Receptor = β -adrenergic receptor Primary target = adenylate cyclase Effect: Activates PKA, which activates glycogen phosphorylase, which catalyzes breakdown of glycogen to glucose-1-P that enters glycolysis. Thus, get burst of energy within seconds.
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This note was uploaded on 05/30/2010 for the course BIS BIS 104 taught by Professor Privalsky during the Spring '09 term at UC Davis.

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Lecture12 - Lecture 12 5/13/10 Background reading: MBOC 5th...

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