Lecture13 - Lecture 13 Background reading MBOC 5th Edition Chapter 15 Chapter 17 Chapter 18 Chapter 20 MBOC 4th Edition Chapter 15 Chapter 17 pages

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Lecture 13 5/18/10 Background reading: MBOC 5 th Edition: Chapter 15: pages 921-930 Chapter 17: pages 1053–1055; 1060-1063 Chapter 18: pages 1115 – 1118 Chapter 20: pages 1205 – 1210 and 1234 - 1236 MBOC 4 th Edition: Chapter 15: pages 871 – 880 Chapter 17: pages 983 -986 and 1014 - 1020 Outline: Ras proteins Summary of cell signaling pathways Cell cycle Regulation of Cdk activity Checkpoints and feedback controls Growth factors Cancer Oncogenes
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One result of adaptor binding to receptors is the activation of Ras proteins. Ras proteins Members of family of monomeric GTPases Contain a covalently attached lipid tail that anchors them to the cytosolic side of the plasma membrane. Ras proteins relay signals from receptor kinases to the nucleus to stimulate cell proliferation and division.
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When Ras is bound to GTP, it activates a serine/threonine phosphorylation cascade that results in activation of MAP kinases (Mitogen activated protein kinases).
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Summary of Cell Signaling Pathways Covered in this Class Autophosphoryla- tion G Protein-linked receptors Enzyme-linked receptor tyro- sine kinases G S G olf G t G q Adenylate cyclase Cyclic AMP Protein kinase A (A-kinase) cAMP gated channels Adenylate cyclase Cyclic AMP Cyclic GMP phosphodies- terase Na + channels Phospho- lipase C- β IP 3 Diacyl- glycerol Ca ++ Calmodulin CaM-kinases Protein kinase C Proteins with SH 2 and SH 3 domains Ras MAP Kinases
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Cell cycle Universal process by which cells reproduce – underlies the growth and development of all living organisms. Cell division is complex process involving duplication of DNA, organelles, centrosomes and cytokinesis. Cells must also increase mass. M phase: Mitotic phase. Nuclear envelope breaks down, DNA condenses into chromosomes, get mitotic spindle, and ends with cytokinesis. ER and Golgi disassemble into vesicles. G
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This note was uploaded on 05/30/2010 for the course BIS BIS 104 taught by Professor Privalsky during the Spring '09 term at UC Davis.

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Lecture13 - Lecture 13 Background reading MBOC 5th Edition Chapter 15 Chapter 17 Chapter 18 Chapter 20 MBOC 4th Edition Chapter 15 Chapter 17 pages

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