Lecture14 - Lecture 14 5/20/10 Background reading: MBOC 5th...

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Lecture 14 5/20/10 Background reading: MBOC 5 th Edition: Chapter 19: pages 1178 – 1202 MBOC 4 th Edition: Chapter 19: pages 1090 – 1100 and pages 1118 -1124 Apoptosis Extracellular Matrix Ground substance Cellulose Collagen Filler material Other components of the ECM Fibronectin Glycans as signals Integrins
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Apoptosis Programmed cell death. If cells die from damage (necrosis), they usually swell, burst and spill their contents over neighbors, eliciting an inflammatory response. Some cells die in tidy fashion. Nucleus condenses, cell shrivels and change surface chemistry so recognized by macrophages. Are engulfed by macrophages with no leakage of cytosolic components.
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Apoptosis involves an intracellular proteolytic cascade that is mediated by a family of proteases that have a cysteine at their active site and cleave their target proteins at specific aspartic acids. Caspases are synthesized in the cell as inactive precursors (procaspases). They are activated by proteolytic cleavage by other caspases and once activated they cleave and activate other caspases, thus resulting in a proteolytic cascade. One very interesting change in an apoptotic cell is that the phosphatidylserine flips to the outside of the bilayer where it can serve as a marker for apoptotic cells.
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Extracellular Matrix Intricate network of molecules constituting the extracellular space. Composed of variety of proteins and polysaccharides that are secreted by local cells and assembled into an organized meshwork in close association with the cells that produce them. Two Categories: 1) Ground substance that provides tensile strength and resistance 2) Molecules embedded in ground substance that help promote adhesion, communication and migration. Ground substance
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Lecture14 - Lecture 14 5/20/10 Background reading: MBOC 5th...

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