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Lecture15 - Lecture 15 Background reading MBOC 5th Edition...

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Lecture 15 5/25/10 Background reading: MBOC 5 th Edition: Chapter 19: 1133 – 1147; Chapter 24: pages 1524 – 1533. MBOC 4 th Edition: Chapter 19: pages 1080 – 1088; Chapter 25: pages 1453 – 1457. Outline: Cell-cell adhesion Cadherins Selectins Neural cell adhesion molecules (N-CAM) Innate Immunity Complement Phagocytosis
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Cell-cell adhesion By middle of the 20 th century developmental biologists recognized that animal cells can often be dissociated from one another by treating them with chelating agents which are chemicals that can form several bonds to a single metal ion. EDTA is a common chelating agent often used to sequester calcium and magnesium from solution by forming complexes with the metal ions. Work on invertebrates, such as sponges, showed that one can dissociate them into their individual cells by treating them with an EDTA solution and could get the cells to reassociate by removing the EDTA and adding calcium. If one mixed the dissociated cells from sponges of two different colors, and then added calcium, it was found that the cells would sort themselves out and reassociate with cells of the same color. Ca ++
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