Lecture16 - Lecture 16 5/27/10 Background reading: MBOC 5...

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Unformatted text preview: Lecture 16 5/27/10 Background reading: MBOC 5 th Edition: Chapter 25: pages 1539 - 1569 MBOC 4 th Edition: Chapter 24: pages 1363 -1371 and pages 1375 1384 Outline: The Adaptive Immune System Lymphocytes Humoral immune response Classes of antibodies Clonal selection Immune response Class switch Somatic hypermutation Generation of antibody diversity Prerequisites of a good defense system: Specificity Ability to destroy the enemy Memory The Adaptive Immune System Present in vertebrates Two main types of immune responses: 1) Humoral produce antibodies 2) Cell-mediated cells interact with other cells Lymphocytes Develop from hemopoietic stem cells in fetal liver and adult bone marrow. About 2 x 10 12 lymphocytes in human body. Comparable to cell mass of liver or brain. Lymphocytes constantly recirculate between blood and secondary lymphoid tissues. Humoral Immune Response (Production ofAntibodies) Antibodies function by recognizing antigen and initiating events leading to destruction. In lecture 2, we have already covered the structure of immunoglobulin and antigen- antibody interactions. We will now see how these interactions lead to the destruction of the pathogen. The Fc region of antibodies are involved in destruction of the pathogens Phagocytosis Complement fixation Classes of antibodies 5 classes each contains H and L chains Distinguished by H chains IgM IgD IgG IgA IgE Heavy chains Light chains or or or or or % of total Ig in blood 10 < 1 75 15 < 1 Activates com- plement ++++ - ++ -- Binds to macro- phages and neutrophils -- + -- Binds to mast cells and baso- phils ---- + Number of 4 chain units 5 1 1 1 or 2 1 IgG IgA IgM...
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Lecture16 - Lecture 16 5/27/10 Background reading: MBOC 5...

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