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article2_Hwang_etal_2004

article2_Hwang_etal_2004 - Evidence of a Pluripotent Human...

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DOI: 10.1126/science.1094515 , 1669 (2004); 303 Science et al. Woo Suk Hwang, Cell Line Derived from a Cloned Blastocyst Evidence of a Pluripotent Human Embryonic Stem This copy is for your personal, non-commercial use only. . clicking here colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others . here following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles (this information is current as of May 21, 2010 ): The following resources related to this article are available online at www.sciencemag.org http://www.sciencemag.org/cgi/content/full/sci;310/5755/1769 A correction has been published for this article at: http://www.sciencemag.org/cgi/content/full/303/5664/1669 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/1094515/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/cgi/content/full/303/5664/1669#related-content http://www.sciencemag.org/cgi/content/full/303/5664/1669#otherarticles , 6 of which can be accessed for free: cites 27 articles This article 287 article(s) on the ISI Web of Science. cited by This article has been http://www.sciencemag.org/cgi/content/full/303/5664/1669#otherarticles 52 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/development Development : subject collections This article appears in the following registered trademark of AAAS. is a Science 2004 by the American Association for the Advancement of Science; all rights reserved. The title Copyright American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005. (print ISSN 0036-8075; online ISSN 1095-9203) is published weekly, except the last week in December, by the Science on May 21, 2010 www.sciencemag.org Downloaded from
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ological grouping of the genotypes through- out the epidemic (Fig. 2) (table S2). In tracing the molecular evolution of SARS-CoV in China, we observed that the epidemic started and ended with deletion events, together with a progressive slowing of the nonsynonymous mutation rates and a common genotype that predominated during the latter part of the epidemic. The mecha- nistic explanation for the selective adaptation and purification processes that led to such genomic evolutionary changes in SARS-CoV requires further work ( 29 ). Nonetheless, this study has provided valuable clues to aid fur- ther investigation of this remarkable evolu- tionary tale. We have sequenced the complete S gene (GenBank accession number AY525636) from an oropharyngeal swab sample (sam- pling date, 22 December 2003) collected from the most recent index patient of the city of Guangzhou (onset date, 16 December 2003; hospitalized 20 December 2003; www.wpro.who.int/sars/docs/pressreleases/ pr_27122003.asp). Phylogenetic analysis of this S gene sequence with those from the human SARS-CoV and palm civet SARS-
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