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Unformatted text preview: a) p21 protein b) Bcl-2 family proteins such as Bad & Bax. p21 binds to and inactivates cdK/cyclin complex at G1 / S to stop cell cycle Bad / Bax proteins interact with surface of mitochondria to trigger leakage of cytochrome c Cytochrome c activates apoptososme complex and initiates caspase hydrolytic cascade. 8. What are caspases, and what is their principle function? (4 pts) DEFINITION: A special family of proteases that are activated during the execution phase of apoptosis. FUNCTION: Cleavage and digestion of specific targets such as nuclear lamins, cytoskeletal proteins, DNA repair enzymes and the activation of DNAses, such as CAD Demo...
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This note was uploaded on 05/31/2010 for the course BIO 1B taught by Professor Carlson,mischel,power during the Spring '07 term at University of California, Berkeley.
- Spring '07