5 - Monday, October 5th, 2009 Biochemistry 405 Lecture # 03...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Monday, October 5 th , 2009 Biochemistry 405 – Lecture # 03 Kane Hall 130 10:30- 11:20 am Lecturer: Wim Hol Slide Set #2: Slides no 31, 33 and 34 of slide set #1 removed Slide 32 of set #1: text removed
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Outline - Amino acids A. Structures B. Acid - base properties - Amino Acid Modifications -Peptides - Biological Peptides - Peptide Bond
Background image of page 2
What you need to know. Amino acids: 2. pK values of side chains when residues 3. Properties of side chains - aliphatic, aromatic, polar, charged, etc. 4. Amino acid modifications 5. Biological amino acids 1. Dipeptide and oligopeptide formation 2. Biological peptides 3. Nature of the peptide bond 4. pK values of N-terminal NH 2 and C-terminal -COOH.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Amino acid structure General structure of an α -amino acid A zwitterionic α -amino acid At neutral pH the amino group is protonated and the carboxylic acid is deprotonated.
Background image of page 4
An amino acid with a polar side chain Serine = Ser = S Side chain hydroxyl Carboxylate α -Amino group C α Carbon Atom C β Carbon Atom
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Three amino acids with a non-polar side chain Ala Ile Phe Note that isoleucine (Ile) is one of only two amino acids having a side chain which is chiral (The other one is Thr) I n c r e a s i g h y d o p b t f
Background image of page 6
Lehninger 4/e Fig 3.5 Note that the Proline is unique: Its side chain makes a ring by forming a bond with its main chain nitrogen. Note that the Glycine is unique: It has no side chain. Amino acids with an aliphatic, nonpolar side chain Not many H-bond acceptors or donors in the side chains of all these amino acids. Only the S in the Met is a rather poor H-bond acceptor.
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Amino acids with an uncharged, polar side chain Cys is quite special: 1. The pK of its SH is ~ 8.4 2. The S - is a good nucleophile 3. It is good in coordinating metals Plenty H-bond acceptors and donors in the side chains of all these amino acids! Lehninger 4/e
Background image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 06/03/2010 for the course BIOL BIO 101 taught by Professor Drumheller during the Spring '10 term at University of Washington.

Page1 / 33

5 - Monday, October 5th, 2009 Biochemistry 405 Lecture # 03...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online