mol3 - BIMM100 Lecture 3! Another !big day of RNA! Making...

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BIMM100 Lecture 3 big day of RNA Making more DNA Continuing in MCB , Ch. 4 LP OH – starting next week Tues 10:50-noon Mon. 9:30-10:30 2100A or 2130 Pac Hall http://www.youtube.com/watch?v=u9dhO0iCLww Another Saving Printing? Slides 6-15 from L2
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Mon: 1 pm York 3000A - Full * Tues: 12 pm WLH2114 – 15 spaces Wed: 11 am Center 217A- Full * 12 pm Center 217A- Full * 7 pm York 3000A - 12 spaces Thurs: 8 am Center 201A – 14 spaces 11am TM102-1- 9 spaces 2 pm Center 201 - Full * Fri: 12 pm Center 218 - 6 spaces 1 pm WLH2209 - 11 spaces Problem Sets on WebCT - linked to TA TA Advice: Treasure (and jot down!) questions arising in lecture. Bring to OH & sections. * Choose another section?
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Key Molecular Processes Transcription –> Translation mRNAs - coding tRNAs - decoding rRNAs - translating
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FINISHING TRANSLATION The Code Decoders - tRNA & amino acylsynthetases tRNA structure and function ‘Wobble’ basepairing rRNA and ribosomes The Process initiation > elongation > termination Inhibiting the process: antibiotics and toxins DNA REPLICATION Overview Problems to solve Initiation Bi-directional synthesis and Polarity Key Processes: Translation and DNA Replication
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mRNA tRNA rRNA structure decoding specifcity synthetases structure + Function in ribosomes Another big day of RNA transcribed From DNA processed in nucleus decoded in cytoplasm translation
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MCB 4-17 three roles of RNA translation -- the process decoding building coding mRNA tRNA Ribosome - rRNA + protein
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I = inosine T = thymine Y = pseudouridine m = methyl group MCB 4-20a Ala modifed bases D = dihydrouridine Usually non-templated tRNA in 2 dimensions (yeast tRNA ala )
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MCB 4-20b three-dimensional view of tRNA 30-40 tRNA genes in bacteria 50-100 in animals and plants
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MCB 4-21 ʻ wobble ʼ pairing allows non-standard interactions G-U ~ G -C UUU, UUC are both read by tRNA with GAA anticodon (PHE) A - rare in wobble pos ʼ n,
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This note was uploaded on 06/03/2010 for the course BIMM Pillus taught by Professor Molecularbiology during the Spring '10 term at UCSD.

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mol3 - BIMM100 Lecture 3! Another !big day of RNA! Making...

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