mol13 - L13 BIMM100 - nishing Ch. 6; begin Ch. 7!...

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L13 BIMM100 -- fnishing Ch. 6; begin Ch. 7 Requests For midterm re-evaluation due today noon in 3100E Pacifc Hall Chromosomes and Genomes on to Regulation oF Expression got talent? http://8e.devbio.com/article.php?id=235 needed For “The Histones” Song Today ʼ s experiments & techniques – defning Functional elements oF chromosomes – determining that the RNA component oF telomerase provides template inFormation – fnding genes in silico (by computational methods) – biochemical defnition oF 3 distinct RNA polymerases
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Chromosomes and genomes chromosome structure required parts special case: telomere replication Using sequence information comparisons and predictions with genomics and bioinformatics Regulating gene expression:transcription
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Chromosome characteristics are species-specifc Reeves muntjac Indian muntjac number, sizes, structure (pos ʼ n oF centromeres, etc) MCB 6-40
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What elements are required for chromosomal function? origins of DNA replication centromere - means of segregation telomeres - means of stabilization Question was answered by sequential construction and transformation assay of shuttle vectors ʻ enough ʼ DNA
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What elements are required for chromosomal function? origins of DNA replication - ARS element centromere - means of segregation telomeres - means of stabilization ʻ enough ʼ DNA MCB 6-46
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What elements are required for chromosomal function? origins of DNA replication centromere - means of segregation telomeres - means of stabilization ʻ enough ʼ DNA MCB 6-46 Simple - yeast ~ 110 basepairs ʻ Complex ʼ - metazoans 2-4 Megabases of simple sequence repeats
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What elements are required for chromosomal function?
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This note was uploaded on 06/03/2010 for the course BIMM Pillus taught by Professor Molecularbiology during the Spring '10 term at UCSD.

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mol13 - L13 BIMM100 - nishing Ch. 6; begin Ch. 7!...

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