mol17 - BIMM 100 Lecture 18 Post-transcriptional control,...

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http://www-biology.ucsd.edu/genericsurvey/studenttaeval.jsp BIMM 100 Lecture 18 Post-transcriptional control, cont ʼ d. Ch. 8 Read Classic Experiment 8.1 online Catalysis without proteins -- the discovery of self-splicing RNA (Not covering TOR pathway or eIF2 kinases p. 353-356) You can help! Please complete Exams available for pickup 3100E Pacific Hall LP OH are Wednesday this week (not Today)
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Post-transcriptional gene control Overview Capping RNA binding proteins Splicing Spliceosomes Variations: Self-splicing Coordinating processes Regulating processing Alternative splicing Rep. & activators important e.g.s RNA editing mRNA transport Processing rRNA &tRNA
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regulation by splicing tissue-specifc splicing: fbronectin sexual diFFerentiation in Drosophila cascades oF negative and positive regulation neuronal-specifc splicing mixtures oF alternatively spliced transcripts In general, alternative splicing appears to be regulated by RNA-binding proteins that bind specifcally near regulated splicing sites. May act both positively and negatively to enhance or inhibit particular splicing Factors a bounty of interesting examples
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Alternative splicing: sex determination Key: sex-specifc repressors oF splicing MCB 8-16 Sxl protein present only in female embryos initially, transcribed only in females. Later …. in males, splicing includes an exon with an ʻ early stop ʼ Sxl binding prevents U2 sn RNP assoc ʼ n, exon 3 is skipped in females, further expression of Sxl protein ….
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Alternative splicing: sex determination MCB 8-16 Key: sex-specifc repressors oF splicing
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mol17 - BIMM 100 Lecture 18 Post-transcriptional control,...

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