mol19 - Lecture 19 Post-transcriptional control, the end.!...

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Lecture 19 Post-transcriptional control, the end. Ch. 8 Read Classic Experiment 8.1 online Catalysis without proteins -- the discovery of self-splicing RNA (Not covering TOR pathway or eIF2 kinases p. 353-356) You can help! Please complete http://www-biology.ucsd.edu/genericsurvey/studenttaeval.jsp
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About the fnal Do not sit in back row Every other seat -- pay attention in long rows No calculators necessary No electronic devices Exam data will be posted to WebCT
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Post-transcriptional control Multiple cytoplasmic mechanisms Micro-RNAs -- translation RNA interference --degrades mRNAs More classic mechanisms of degradation/translation control RNA surveillance Processing rRNAs and tRNAs Stability Localization (Not covering TOR pathway or eIF2 kinases p. 353-356) finishing words . ...
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Where are things happening? Specialized nuclear domains Nucleolus - rRNA transcription (except 5S) and ribosome assembly - assembly of secretion complexes (?) Cajal bodies - RNP complex assembly spliceosomal RNPs telomerase RNP (?) Nuclear speckles - warehouses for snRNP storage PML (Promyelocytic Leukemia) Nuclear Bodies - assembly of DNA repair complexes - apoptotic complexes (?) - sites of SUMOylation http://www.abcam.com/index.html?pageconfg=resource&rid=11025&pid=10026
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Post-transcriptional control Multiple cytoplasmic mechanisms Micro-RNAs -- translation RNA interference --degrades mRNAs More mechanisms of degradation/translation control RNA surveillance Processing rRNAs and tRNAs Stability Localization short RNAs, basepairing with targets similar enzymology
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mol19 - Lecture 19 Post-transcriptional control, the end.!...

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